Carbon Disulfide → HCID 13561994, compound

HRID 1249081Notes

Reaction equation

HRID 1249081 reaction equation
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([NH2:16])=[O:15])[NH:2]1.C(N(CC)CC)C.[C:24](=[S:26])=[S:25].[Cl:27][C:28]1[CH:35]=[CH:34][C:31]([CH2:32]Cl)=[CH:30][CH:29]=1>C(O)C>[Cl:27][C:28]1[CH:35]=[CH:34][C:31]([CH2:32][S:25][C:24]([N:2]2[C@H:3]([C:14]([NH2:16])=[O:15])[CH2:4][C:5]3[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[NH:12][C:13]=3[CH2:1]2)=[S:26])=[CH:30][CH:29]=1

Participants

6

Reactant 4

HCID 6348Carbon DisulfideHCID 77231-Chloro-4-(chloromethyl)benzeneHCID 8471TriethylamineHCID 15573651HCID 15573651, compound

Product 1

HCID 13561994HCID 13561994, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as described in Example 53, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxamide (0.71 g), triethylamine (0.46 ml), carbon disulfide (0.22 ml), 70% ethanol (20 ml) and 4-chlorobenzyl chloride (0.53 g) are reacted and treated to give the title compound (0.97 g, 71%) as white powder.

Workup

  1. customare reacted
  2. additiontreated

Sources & evidence

ORD record
ord-d53b5744ee0e41ae9bda72a2bee2da35
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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