Methyl iodide → HCID 178504088, compound

HRID 1249083Notes

Reaction equation

HRID 1249083 reaction equation
[NH:1]1[C:5]([CH:6]2[CH2:18][C:17]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[NH:10][C:9]=3[CH2:8][NH:7]2)=[N:4][N:3]=[N:2]1.C(N(CC)CC)C.[C:26](=[S:28])=[S:27].[CH3:29]I>C(O)C>[NH:4]1[C:5]([CH:6]2[CH2:18][C:17]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[NH:10][C:9]=3[CH2:8][N:7]2[C:26]([S:28][CH3:29])=[S:27])=[N:1][N:2]=[N:3]1

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 178419865HCID 178419865, compound

Product 1

HCID 178504088HCID 178504088, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as described in Example 53, (3RS)-3-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydro-β-carboline (0.257 g), triethylamine (0.23 ml), carbon disulfide (0.05 ml), 70% ethanol (4 ml) and methyl iodide (0.055 ml) are reacted and treated. The product is crystallized from chloroform to give the title compound (75 mg), m.p. 203°-205° C. (decomp.).

Workup

  1. customare reacted
  2. additiontreated
  3. customThe product is crystallized from chloroform

Sources & evidence

ORD record
ord-2590fb5b2b124826b0e3df4b1473bcbe
Source dataset
uspto-grants-1986_12
Patent number
US04628057

Reaction notes

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