Phosphorus oxychloride → 2-Chloro-4,6-dimethyl-3-pyridinecarbonitrile

HRID 1249317Notes

Reaction equation

[C:1]([C:3]1[C:4](=O)[NH:5][C:6]([CH3:10])=[CH:7][C:8]=1[CH3:9])#[N:2].P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:4]1[C:3]([C:1]#[N:2])=[C:8]([CH3:9])[CH:7]=[C:6]([CH3:10])[N:5]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 698563-Cyano-4,6-dimethyl-2-hydroxypyridine

Product 1

HCID 2232612-Chloro-4,6-dimethyl-3-pyridinecarbonitrile

Procedure

2-Chloro-3-cyano-4,6-dimethylpyridine was prepared from 3-cyano-4,6-dimethylpyrid-2-one and phosphorus oxychloride following the procedure of Kametani and Sato (Yakugaka Kenyu 34, 117, 1962).

Sources & evidence

ORD record: ord-5b6600c3d1f7466e858e9a3af8f1837b
Source dataset: uspto-grants-1986_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04631081

Reaction notes

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