Morpholine → HCID 22495826, compound

HRID 1249697Notes

Reaction equation

HRID 1249697 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](F)(=[O:18])=[O:17])=[CH:12][CH:11]=1)=[O:8].[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)(=[O:18])=[O:17])=[CH:12][CH:11]=1)=[O:8]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 8471TriethylamineHCID 22495894HCID 22495894, compound

Product 1

HCID 22495826HCID 22495826, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

120.00 g (0.33 mol) of 4-(5-chloro-2-nitro-benzoylamino)-benzenesulfonyl fluoride, 29.10 g (0.33 mol) of morpholine and 33.85 g (0.33 mol) of triethylamine were stirred in 1200 ml of toluene at 60° C. for 2 days. The precipitated solid was filtered off with suction and recrystallized from acetone/n-hexane. 102.10 g (71%) of the title compound having a melting point of 243-245° C. were obtained.

Workup

  1. filtrationThe precipitated solid was filtered off with suction
  2. customrecrystallized from acetone/n-hexane
  3. customwere obtained

Sources & evidence

ORD record
ord-7f35f79445954fec89a44f7a4da77281
Source dataset
uspto-grants-2002_01
Patent number
US06335334B1

Reaction notes

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