Oxalyl chloride → HCID 14265167, compound

HRID 1249751Notes

Reaction equation

HRID 1249751 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:8](CC(O)=O)=[CH:9][CH:10]=[CH:11][CH:12]=1>CN(C)C=O.C(Cl)Cl>[C:7]1([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:12]([CH2:1][C:2]([Cl:4])=[O:3])=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 2633732-Biphenylacetic acid

Product 1

HCID 14265167HCID 14265167, compoundYield 95.3%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (246 μl, 2.86 mmol) and one drop of dimethylformamide were added dropwise to a suspension of biphenylacetic acid (30 mg, 1.41 mmol) in methylene chloride (10 ml). The mixture was stirred at room temperature for 20 minutes. The solvent was evaporated and the residue was coevaporated with toluene twice to give 310 mg of the title product as a yellow solid.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-c9fdbf6dc8024149a76562572f958550
Source dataset
uspto-grants-2002_01
Patent number
US06335324B1

Reaction notes

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