Magnesium → HCID 18329057, compound

HRID 1249947Notes

Reaction equation

C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[C:11]1[O:14][CH2:15][O:16][C:10]1=[CH:9][CH:8]=2)=[O:4].[Mg]>>[CH2:15]1[O:16][C:10]2[C:11](=[C:12]3[C:7](=[CH:8][CH:9]=2)[NH:6][CH:5]([C:3]([OH:4])=[O:2])[CH2:13]3)[O:14]1

Participants

Reactant 2

HCID 5462224Magnesium2×

HCID 54110016HCID 54110016, compound

Product 1

HCID 18329057HCID 18329057, compound

Procedure

This compound was prepared from 4,5-methylenedioxyindole-2-carboxylic acid methyl ester as described in example 1. However this time 10 equivalence of magnesium turnings were used instead of 2-3 eq. of magnesium turnings. The product was purified by column chromatography on silica gel using 7:3 petroleum spirit:ethyl acetate as eluent.

Workup

customThe product was purified by column chromatography on silica gel using 7:3 petroleum spirit

Sources & evidence

ORD record: ord-2a88eaa187644befbdeaaaffce7f7bd5
Source dataset: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06335360B1

Reaction notes

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