反应详情

温度

35 °C

A suitable reactor vessel was charged with 265 g (1 Mol) of 3-hydroxy-2-phenylquinoline-4-carboxylic acid and ethyl acetate (25 volumes, 5.98 Kg, 6.63 L). The yellow slurry was heated at 30-40° C., and the ethyl acetate distilled off under high vacuum until 15 volumes of solvent remained in the still pot. After vacuum distillation, the yellow slurry was cooled to 20-25° C. Added triethylamine (3.0 Mol, 0.31 Kg, 0.42 L) to afford a dark orange solution. Cooled the solution to −2° C. and slowly added thionyl chloride (1.05 Mol, 0.13 Kg, 0.080 L), over approx. 30 minutes, keeping the solution temperature less than 2° C. After complete addition, the tan slurry was stirred at 25° C. for 1 hour. Added (S)-1-phenyl-n-propylamine (1.1 Mol, 0.16 Kg, 0.17 L) and heated at 65-70° C. for about 3 hours. After 3 hours at 65-70° C., cooled the reaction to 20-25° C. The reactor was charged with ethyl acetate (10 volumes, 2.39 Kg, 2.65 L) and stirred for 5-10 minutes. Added deionized water (15 volumes, 3.98 Kg, 3.98 L). Stirred the reactor contents at ambient temperature for 5 minutes and then separated the phases. Washed the organic layer with 0.5 M aq. citric acid (2×10 volumes, 2×2.8 Kg, 2×2.6 L) followed by deionized water (5 volumes, 1.3 Kg, 1.3 L). At this point, a sample of the organic phase can be removed and assayed by HPLC to determine the presence and content of the freebase form of the desired product. (Note: Typical solution yields range from 80-84% and one can proceed assuming an 80% solution yield). Added toluene (15 volumes, 3.44 Kg, 3.98 L) and concentrated the solution via vacuum distillation until a final reactor volume of 2.2 L was obtained (this represents 7 volumes of solvent remaining based on freebase available). The reactor was charged with IPA (isopropyl amine) (3 volumes based on freebase available), 0.72 Kg, 0.92 L) and the reactor contents warmed to 70° C. to afford a clear solution. To the solution, 58.4 g (2 equiv.) of HCl (g) was bubbled in slowly to precipitate the desired product. The precipitate was cooled to 0° C. and held for about 1 hour. The product was collected by suction filtration. The reaction flask was rinsed with TBME (4 volumes, 0.90 Kg, 1.22 L) and the TBME used as a rinse to wash the filter cake. This washing was repeated with an additional portion of TBME (4 volumes, 0.90 Kg, 1.22 L). The product was dried to a constant weight in a vacuum oven at 70° C./<1.0 mm Hg. The yield of desired product was 301 g, affording a 72% yield of a light beige product: mp=179-180° C., IR (cm−1) 2450, 1627, 1322; 1H NMR (300 MHz, DMSO-d6) δ9.20 (1H, d, J=8.2 Hz), 8.19 (1H, d, J=8.4 Hz), 7.96 (2H, m), 7.71 (1H, m), 7.60 (5H, m), 7.44 (2H, m), 7.37 (2H, m), 7.27 (1H, m), 5.02 (1H, q, J=7.5 Hz), 1.81 (2H, m), 0.94 (3H, t, J=7.2 Hz). 13C NMR (100.625 Mhz) δ169.8, 151.7, 144.8, 143.3, 139.7, 134.9, 131.3, 129.9, 129.8, 128.3, 128.2, 128.0, 126.8, 126.7, 126.5, 125.7, 123.9, 55.0, 29.3, 11.1.

1. distillationthe ethyl acetate distilled off under high vacuum until 15 volumes of solvent
2. distillationAfter vacuum distillation
3. temperaturethe yellow slurry was cooled to 20-25° C
4. temperatureCooled the solution to −2° C.
5. customthe solution temperature less than 2° C
6. additionAfter complete addition
7. waitAfter 3 hours at 65-70° C.
8. temperaturecooled
9. customthe reaction to 20-25° C
10. stirringstirred for 5-10 minutes
11. additionAdded
12. stirringStirred the reactor contents at ambient temperature for 5 minutes
13. customseparated the phases
14. washWashed the organic layer with 0.5 M aq. citric acid (2×10 volumes, 2×2.8 Kg, 2×2.6 L)
15. customAt this point, a sample of the organic phase can be removed
16. custom(Note: Typical solution yields
17. customyield)
18. concentrationAdded toluene (15 volumes, 3.44 Kg, 3.98 L) and concentrated the solution
19. distillationvia vacuum distillation until a final reactor volume of 2.2 L
20. customwas obtained (
21. temperaturewarmed to 70° C.
22. customto afford a clear solution
23. customto precipitate the desired product
24. temperatureThe precipitate was cooled to 0° C.
25. waitheld for about 1 hour
26. filtrationThe product was collected by suction filtration
27. washThe reaction flask was rinsed with TBME (4 volumes, 0.90 Kg, 1.22 L)
28. washa rinse
29. washto wash the filter cake
30. customThe product was dried to a constant weight in a vacuum oven at 70° C./<1.0 mm Hg