Anisole → HCID 18400084, compound

HRID 1250058Notes

Reaction equation

HRID 1250058 reaction equation
C([NH:5][S:6]([C:9]1[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]3[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[C:17]([Cl:36])[CH:16]=2)=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:8])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[Cl:36][C:17]1[CH:16]=[C:15]([C:10]2[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:20]=[CH:19][C:18]=1[CH2:21][N:22]1[C:26]([CH:27]=[O:28])=[C:25]([Cl:29])[N:24]=[C:23]1[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 17775489HCID 17775489, compound

Product 1

HCID 18400084HCID 18400084, compoundYield 111.5%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.5 g of 3′-chloro-4′-(4-chloro-5-formyl-2-phenylimidazol-1-ylmethyl)-biphenyl-2-sulfonic acid tert-butylamide and 340 μl of anisole are dissolved in 10 ml of trifluoroacetic acid and the solution is stirred at RT for 24 h. The volatile constituents are removed in vacuo, the residue is taken up twice using 50 ml of toluene each time and the volatile constituents are again removed in vacuo. 1.5 g of a colorless foam are obtained.

Workup

  1. customThe volatile constituents are removed in vacuo
  2. customthe volatile constituents are again removed in vacuo

Sources & evidence

ORD record
ord-3468790ddc084ae3b103faea41d8291e
Source dataset
uspto-grants-2002_01
Patent number
US06335451B1

Reaction notes

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