Potassium Carbonate → HCID 53979024, compound

HRID 1250107Notes

Reaction equation

HRID 1250107 reaction equation
Br[CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].C(=O)([O-])[O-].[K+].[K+].[Br:16][C:17]1[C:18]([CH3:24])=[C:19]([OH:23])[CH:20]=[CH:21][CH:22]=1>CC(C)=O>[C:6]([O:5][C:3](=[O:4])[CH2:2][O:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([Br:16])[C:18]=1[CH3:24])([CH3:9])([CH3:8])[CH3:7]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 111714303-Bromo-2-methylphenol

Product 1

HCID 53979024HCID 53979024, compoundYield 101.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Tert-butyl bromoacetate (1.08 mL, 7.27 mmol) and potassium carbonate (2.01 g, 14.55 mmol) were added to a solution of 3-bromo-2-methylphenol (1.29 g, 6.92 mmol) in acetone (17 mL), and the mixture was stirred at room temperature for 5 hours under a nitrogen atmosphere. The mixture was filtered, and the filtrate was evaporated to dryness to give (3-bromo-2-methylphenoxy)acetic acid tert-butyl ester as a pale yellow oil (2.12 g, 100%).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-51c7ec62948f4cfbb44bc4ab0116571d
Source dataset
uspto-grants-2002_01
Patent number
US06335459B1

Reaction notes

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