Benzenamine, 3,5-bis(trifluoromethyl)- → HCID 18328565, compound

HRID 1250121Notes

Reaction equation

HRID 1250121 reaction equation
[C:1](Cl)(=[O:5])[C:2](Cl)=[O:3].[F:7][C:8]([F:21])([F:20])[C:9]1[CH:10]=[C:11]([CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:15]=1)[NH2:12]>>[F:7][C:8]([F:20])([F:21])[C:9]1[CH:10]=[C:11]([NH:12][C:1](=[O:5])[C:2]([NH:12][C:11]2[CH:13]=[C:14]([C:16]([F:17])([F:18])[F:19])[CH:15]=[C:9]([C:8]([F:7])([F:20])[F:21])[CH:10]=2)=[O:3])[CH:13]=[C:14]([C:16]([F:17])([F:18])[F:19])[CH:15]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 65578Oxalyl chloride

Product 1

HCID 18328565HCID 18328565, compound

Procedure

Into a 250 mnL Schlenk vessel was placed 100 mL of dry TBF, 3.50 g of oxalyl chloride and 12.4 g of 3,5-bis(trifluoromethyl)aniline. The mixture was refluxed under argon for 12 hours and then allowed to cool. All of the solvent was removed in vacuo to leave a pale brown solid. This was washed with hexane and toluene and pumped dry. Yield 10.33 g.

Workup

  1. temperatureThe mixture was refluxed under argon for 12 hours
  2. temperatureto cool
  3. customAll of the solvent was removed in vacuo
  4. customto leave a pale brown solid
  5. washThis was washed with hexane and toluene
  6. custompumped dry

Sources & evidence

ORD record
ord-d3bf96e5a180428f815e4d66a4129da5
Source dataset
uspto-grants-2002_01
Patent number
US06335303B1

Reaction notes

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