4-Toluenesulfonyl chloride → HCID 10220061, compound

Temperature

25 °C

p-Toluenesulfonyl chloride (782 mg, 4.10 mmol) was added, in one portion, to a stirred solution of (4E)-5-(3-(dimethylamino)phenyl)-4-penten-2-ol (648 mg, 3.16 mmol) in triethylamine (2 mL) and dichloromethane (5 mL) at 10° C. under nitrogen. The cooling bath was removed, and the mixture was stirred at 25° C. for 18 h. Saturated aqueous NaHCO3 (10 mL) was then added and the biphasic mixture was vigorously stirred for 2 h. The layers were separated and the aqueous layer was extracted once with dichloromethane (10 mL). The combined organic layers were dried (Na2SO4) and evaporated, and the residue was combined with DMF (1 mL) and 40% aqueous methylamine (3 mL). This mixture, also biphasic, was vigorously stirred at 25° C. for 18 h, poured into a mixture of 30% aqueous NaOH (1 mL) and saturated aqueous NaCl (25 mL), and extracted with ether (3×20 mL). The ether extracts were dried (Na2SO4) and evaporated, and the residue was chromatographed on 30 g of Merck silica gel 60 (70-230 mesh) with 5% (v/v) methanol, 5% triethylamine (v/v) in benzene. This gave 206 mg (29.9% yield) of yellow oil.

1. customThe cooling bath was removed
2. additionSaturated aqueous NaHCO3 (10 mL) was then added
3. stirringthe biphasic mixture was vigorously stirred for 2 h
4. customThe layers were separated
5. extractionthe aqueous layer was extracted once with dichloromethane (10 mL)
6. dry with materialThe combined organic layers were dried (Na2SO4)
7. customevaporated
8. stirringThis mixture, also biphasic, was vigorously stirred at 25° C. for 18 h
9. additionpoured into a mixture of 30% aqueous NaOH (1 mL) and saturated aqueous NaCl (25 mL)
10. extractionextracted with ether (3×20 mL)
11. dry with materialThe ether extracts were dried (Na2SO4)
12. customevaporated
13. customthe residue was chromatographed on 30 g of Merck silica gel 60 (70-230 mesh) with 5% (v/v) methanol, 5% triethylamine (v/v) in benzene

ORD record

ord-ae5b45e385554339a3006e57ecd67a24

Source dataset

uspto-grants-2002_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06337351B1