Sodium hydride → HCID 18328113, compound

HRID 1250296Notes

Reaction equation

HRID 1250296 reaction equation
[CH2:1]([C:3]1[NH:9][C:8](=[O:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[O:5][CH:4]=1)[CH3:2].[H-].[Na+].Br[CH2:18][CH2:19][CH2:20][CH2:21][Cl:22]>CN(C)C=O>[Cl:22][CH2:21][CH2:20][CH2:19][CH2:18][N:9]1[C:8](=[O:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[O:5][CH:4]=[C:3]1[CH2:1][CH3:2]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 813641-Bromo-4-chlorobutaneHCID 18328025HCID 18328025, compound

Product 1

HCID 18328113HCID 18328113, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

430 mg of 4,5-dihydro-3-ethyl-1,4-benzoxazepin-5-one was dissolved in 10 ml of dimethylformamide, then 110 mg (1.2 equivalents) of 60% sodium hydride was added under ice cooling. This was agitated for 30 minutes, then 480 mg (1.2 equivalents) of 1-bromo-4-chlorobutane was added and the resultant mixture was agitated at room temperature for 6 hours.

Sources & evidence

ORD record
ord-2b598f0061c747a9b147d4931ddf9782
Source dataset
uspto-grants-2002_01
Patent number
US06337397B1

Reaction notes

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