1,4-Dibromobutane → HCID 18328091, compound

HRID 1250299Notes

Reaction equation

HRID 1250299 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH:10]=[C:9]([CH3:12])[NH:8][C:7](=[O:13])[C:6]=2[CH:14]=1.[H-].[Na+].[Br:17][CH2:18][CH2:19][CH2:20][CH2:21]Br>CN(C)C=O>[Br:17][CH2:18][CH2:19][CH2:20][CH2:21][N:8]1[C:7](=[O:13])[C:6]2[CH:14]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[O:11][CH:10]=[C:9]1[CH3:12]

Participants

5

Reactant 3

HCID 80561,4-DibromobutaneHCID 24758Sodium hydrideHCID 18327981HCID 18327981, compound

Product 1

HCID 18328091HCID 18328091, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

416 mg of 4,5-dihydro-7-fluoro-3-methyl-1,4-benzoxazepin-5-one was dissolved in 15 ml of dimethylformamide, then 113 mg (1.2 equivalents) of 60% sodium hydride was added under ice cooling. This was agitated for 30 minutes, then 1 ml (3.6 equivalents) of 1,4-dibromobutane was added and the resultant mixture was agitated at room temperature for 6 hours.

Sources & evidence

ORD record
ord-833696a1434a431aa17cfb5373f65e8a
Source dataset
uspto-grants-2002_01
Patent number
US06337397B1

Reaction notes

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