Propargylamine → HCID 18326417, compound

HRID 1250584Notes

Reaction equation

HRID 1250584 reaction equation
[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7](Cl)[N:6]=1)[CH:2]=[CH2:3].[CH2:19]([NH2:22])[C:20]#[CH:21]>O>[CH2:1]([NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=2)[N:8]=[C:7]([NH:22][CH2:19][C:20]#[CH:21])[N:6]=1)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 239041PropargylamineHCID 183264874-Allylamino-2-chloro-6-nitroquinazoline

Product 1

HCID 18326417HCID 18326417, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To 150 mg (0.57 mmol) of 4-allylamino-2-chloro-6-nitroquinazoline was added 1.61 g (29.16 mmol) of 2-propynylamine, followed by stirring at room temperature for 6 hours. After water was added to the reaction solution was water added, crystals thus precipitated were filtered and recrystallized from ethyl acetate-hexane to give 143 mg (yield: 88.6%) of the title compound.

Workup

  1. additionadded
  2. customcrystals thus precipitated
  3. filtrationwere filtered
  4. customrecrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-26072ec2c1014aea9467fc63d3e95207
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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