反应详情

温度

200 °C

To 25.0 g (146 mmol) of methyl 3-amino-4-methylthiophene-2-carboxylate was added 43.5 g (730 mmol) of urea, and the resulting mixture was heated at 200° C. for 1.5 hours. The mixture was allowed to resume room temperature, and DMF (400 ml) was added thereto, followed by heating under reflux for one hour. After completion of the reaction, ice water was added to the reaction mixture, and crystals thus precipitated were filtered to give 23.0 g (yield: 93.7%) of the title compound.

1. customto resume room temperature
2. temperatureby heating
3. temperatureunder reflux for one hour
4. additionwas added to the reaction mixture, and crystals
5. customthus precipitated
6. filtrationwere filtered