HCID 18326431, compound → HCID 18326505, compound

HRID 1250660Notes

Reaction equation

HRID 1250660 reaction equation
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:11][C:12]1[N:13]=[C:14]([NH:22][C:23](=[O:29])[NH:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:15]2[S:20][CH:19]=[C:18]([CH3:21])[C:16]=2[N:17]=1)[CH:9]=[CH2:10]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:11][C:12]1[N:13]=[C:14]([NH:22][C:23](=[O:29])[NH:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:15]2[S:20][CH:19]=[C:18]([CH3:21])[C:16]=2[N:17]=1)[CH:9]=[CH2:10]

Participants

4

Reactant 2

HCID 18326431HCID 18326431, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18326505HCID 18326505, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 4 N hydrochloric acid-ethyl acetate solution was added dropwise to a solution of 398 mg (1.3 mmol) of 2-allylamino-4-(t-butylcarbamoyl)amino-7-methylthieno[3,2-d]pyrimidine in ethyl acetate under ice cooling. Crystals thus precipitated were filtered out to give 400 mg (yield: 90.3%) of the title compound.

Workup

  1. customCrystals thus precipitated
  2. filtrationwere filtered out

Sources & evidence

ORD record
ord-ca4bbc875ac84b2faaad244f45da4171
Source dataset
uspto-grants-2002_01
Patent number
US06339089B2

Reaction notes

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