HCID 9894515, compound → HCID 18520283, compound

HRID 1250771Notes

Reaction equation

HRID 1250771 reaction equation
[ClH:1].C(OCC)(=O)C.[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:46])[CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH2:10][CH2:9]1>C(OCC)(=O)C>[ClH:1].[O:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:46])[CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 9894515HCID 9894515, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 18520283HCID 18520283, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrochloric acid/ethyl acetate solution (1.2 ml) was added to a solution containing N-(3-morpholinopropyl)-3-[2-(octadecyloxy)phenyl]propanamide (1.88 g) in ethyl acetate (38 ml) at room temperature. After being stirred for 45 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.89 g) as white solid.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Sources & evidence

ORD record
ord-3bc399051a0c47718bcf8bc591994e11
Source dataset
uspto-grants-2002_01
Patent number
US06339154B1

Reaction notes

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