1-Methylpiperazine → 2-(2-Hydroxyphenyl)-1-(4-methylpiperazino)-1-ethanone

HRID 1250778Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[O:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][C:9]1=[O:17]>>[OH:8][C:16]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:10][C:9]([N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)=[O:17]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 683822(3H)-Benzofuranone

Product 1

HCID 185202582-(2-Hydroxyphenyl)-1-(4-methylpiperazino)-1-ethanoneYield 101.7%

Conditions

Temperature: 85 °C

Procedure

N-Methylpiperazine (1.52 g) was added to 2-coumaranone (2.01 g) and stirred for 3.5 hours at 85° C., thereby yielding the entitled compound (3.57 g) as pale brown solid.

Sources & evidence

ORD record: ord-7ba78af36f1645d381e9675a77a3bd69
Source dataset: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06339154B1

Reaction notes

Loading…