HCID 18324764, compound → HCID 18324765, compound

HRID 1250828Notes

Reaction equation

HRID 1250828 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[N:16]=[C:15]2[N:23]2[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[CH3:29][N:26]1[CH2:25][CH2:24][N:23]([C:15]2[N:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[N:16]=2)[CH2:28][CH2:27]1

Participants

4

Reactant 1

HCID 18324764HCID 18324764, compound

Product 1

HCID 18324765HCID 18324765, compoundYield 87.3%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A suspension mixture of 1-(1-benzyl-4-piperidinyl)-2-(4-methylpiperazinyl)-1H-benzimidazole (4.62 g, 11.86 mmol) and Pd(OH)2/C (2.35 g) in MeOH(100 ml) was stirred under hydrogen atmosphere at room temperature for 23 h. The catalyst was removed by filtration and the filtrate was concentrated to give 3.10 g (87%) of title compound as white solid.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cc807c268de946209974da0ae32b015d
Source dataset
uspto-grants-2002_01
Patent number
US06340681B1

Reaction notes

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