Triethylamine → HCID 18323649, compound

HRID 1251326Notes

Reaction equation

HRID 1251326 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19]Br)[CH2:11][CH2:10]1.[F:22][C:23]1[CH:31]=[C:30]2[C:26]([C:27]([C:32]3[CH2:33][CH2:34][NH:35][CH2:36][CH:37]=3)=[CH:28][NH:29]2)=[CH:25][CH:24]=1.C(N(CC)CC)C>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19][N:35]2[CH2:36][CH:37]=[C:32]([C:27]3[C:26]4[C:30](=[CH:31][C:23]([F:22])=[CH:24][CH:25]=4)[NH:29][CH:28]=3)[CH2:33][CH2:34]2)[CH2:11][CH2:10]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 110530726-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleHCID 18323643HCID 18323643, compound

Product 1

HCID 18323649HCID 18323649, compoundYield 69.7%

Procedure

Following the same procedure reported in the Step 2 of EXAMPLE 13, the reaction of 1-(2-methoxyphenyl)-4-(5-bromovaleryl)piperazine (9.29 mmol) with 6-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (3.54 mmol) and triethylamine (4.63 mmol) gave the alkylation product (1.21 g, 53%). mp: 78-81° C.

Sources & evidence

ORD record
ord-4c321ff11ffa4c8faa0bf54503113be4
Source dataset
uspto-grants-2002_01
Patent number
US06342498B1

Reaction notes

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