反应详情

4-Nitroacetophenone(15 g) and N,N-dimethylformamide dimethylacetal(54 g) were refluxed for 1 hour. The reaction mixture was cooled, then crystals precipitate were filtered. To a solution of the crystals obtained (13.5 g) in ethanol (150 ml) was added hydrazine (4.52 g) and p-toluene sulfonic acid monohydrate (0.15 g) and the mixture was refluxed for 1 hours. The solvent was evaporated to dryness and the residue was crystallized from ether to obtain thr title compound (10.1 g).

1. temperatureThe reaction mixture was cooled
2. filtrationcrystals precipitate were filtered
3. customTo a solution of the crystals obtained (13.5 g) in ethanol (150 ml)
4. temperaturethe mixture was refluxed for 1 hours
5. customThe solvent was evaporated to dryness
6. customthe residue was crystallized from ether