HCID 86585139, compound → HCID 9893825, compound

HRID 1251911Notes

Reaction equation

HRID 1251911 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([NH:16][C@@H:17]([CH2:25][CH2:26][S:27][CH3:28])[C:18]([O:20]C(C)(C)C)=[O:19])=[O:15])=[CH:12][CH:11]=[C:10]([O:29][CH:30]([C:37]3[CH:42]=[CH:41][C:40]([F:43])=[CH:39][CH:38]=3)[CH2:31][N:32]3[CH:36]=[CH:35][N:34]=[CH:33]3)[N:9]=2)=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([NH:16][C@@H:17]([CH2:25][CH2:26][S:27][CH3:28])[C:18]([OH:20])=[O:19])=[O:15])=[CH:12][CH:11]=[C:10]([O:29][CH:30]([C:37]3[CH:38]=[CH:39][C:40]([F:43])=[CH:41][CH:42]=3)[CH2:31][N:32]3[CH:36]=[CH:35][N:34]=[CH:33]3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 86585139HCID 86585139, compound

Product 1

HCID 9893825HCID 9893825, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl (2S)-2-{2-(4-fluorophenyl)-6-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]pyrid-3-oylamino}-4-methylsulfanylbutyrate (0.1 g.) in TFA(20 ml.) was stirred at ambient temperature under an inert atmosphere for 30 minutes. The TFA was evaporated away and the residue was converted to the hydrochloride salt to give (2S)-2-{2-(4-fluorophenyl)-6-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]pyrid-3-oylamino}-4-methylsulfanylbutyric acid as a white solid (0.092 g.).

Workup

  1. customThe TFA was evaporated away

Sources & evidence

ORD record
ord-79375ec8b89248c998454811c3b929fc
Source dataset
uspto-grants-2002_01
Patent number
US06342765B1

Reaction notes

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