HCID 53889356, compound → HCID 17866964, compound

HRID 1251920Notes

Reaction equation

HRID 1251920 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]2[C:11]([C:16]([O:18][CH3:19])=[O:17])=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1>[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]2[C:11]([C:16]([O:18][CH3:19])=[O:17])=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 53889356HCID 53889356, compound

Product 1

HCID 17866964HCID 17866964, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A suspension of 10% palladium on carbon (2.5 g) and methyl 3-[2-(4-fluorophenyl)ethenyl]pyridin-2-carboxylate (12.4 g) in ethyl acetate (200 ml) was stirred vigorously under an hydrogen atmosphere at ambient temperature for four hours. The suspension was filtered through Celite and the filtrate concentrated under reduced pressure to give methyl 3-(4-fluoropbenethyl)pyridin-2-carboxylate as a mobile, pale yellow oil (11.72 g).

Workup

  1. filtrationThe suspension was filtered through Celite
  2. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-3b7e6e12daf44631856fe1556f9543d1
Source dataset
uspto-grants-2002_01
Patent number
US06342765B1

Reaction notes

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