反应详情

A mechanically stirred mixture of 22.6 g (0.09 mol) of product of Example 1, 99 g of butyl iodide, 24.84 g of potassium carbonate and 250 ml of acetone was held at reflux for 26 hours and filtered. The acetone filtrate was concentrated and the residue was dissolved in ether. The ether solution was washed with water, dried, and concentrated. The residue was kugelrohr distilled at 0.3 torr to give 32.5 g (99%) of product, nD25 1.4543.

1. temperatureat reflux for 26 hours
2. filtrationfiltered
3. concentrationThe acetone filtrate was concentrated
4. dissolutionthe residue was dissolved in ether
5. washThe ether solution was washed with water
6. customdried
7. concentrationconcentrated
8. distillationThe residue was kugelrohr distilled at 0.3 torr