反应详情

A mixture of 4-methyl-4-p-nitrobenzyloxycarbonylaminovaleric acid p-methoxybenzyl ester (25 g), anisole (25 g) and trifluoroacetic acid (125 ml) was stirred for 15 minutes at room temperature. Evaporation of trifluoroacetic acid gave an oily residue which was then dissolved in diethyl ether. The ether solution was extracted with aqueous sodium carbonate. The aqueous layer was washed with diether ether, acidified with dilute hydrochloric acid and extracted with benzene. The benzene extract was washed with water, dried over anhydrous sodium sulfate and evaporated to give 4-methyl-4-p-nitrobenzyloxycarbonylaminovaleric acid.

1. customEvaporation of trifluoroacetic acid
2. customgave an oily residue which
3. extractionThe ether solution was extracted with aqueous sodium carbonate
4. washThe aqueous layer was washed with diether ether
5. extractionextracted with benzene
6. extractionThe benzene extract
7. washwas washed with water
8. dry with materialdried over anhydrous sodium sulfate
9. customevaporated