反应详情

5.8 g of metallic sodium was added to 300 ml of ethanol and they were reacted to obtain an ethanol solution containing sodium ethoxide. To this solution was added 62.2 g of ethyl N-ethoxycarbonylacetyl-3-ethylaminopropionate, and they were refluxed for 4 hours and allowed to cool. Ethanol was distilled off. Thereto were added ethyl acetate and a dilute aqueous hydrochloric acid solution and the resulting mixture was shaken. The organic layer was separated, water-washed, dried and concentrated to obtain 36.3 g of 3-carboethoxy-1-ethylpiperidine-2,4-dione as an oily matter with an yield of 71%.

1. customwere reacted
2. temperaturewere refluxed for 4 hours
3. temperatureto cool
4. distillationEthanol was distilled off
5. additionThereto were added ethyl acetate
6. customThe organic layer was separated
7. washwater-washed
8. customdried
9. concentrationconcentrated