反应详情

To a hot solution of 154 g of 5-methyl-1H-imidazole-4-carboxylic acid, ethyl ester in 2 liters of absolute ethanol was added dropwise, but rapidly, 100 g of hydrazine hydrate. The solution was stirred at reflux temperature for 3 hours, then 150 ml of hydrazine hydrate was added and the solution was refluxed for 3 days. The mixture was partially evaporated, the solid collected, washed twice with absolute ethanol, then ether and dried, giving 121.3 g of 5-methyl-1H-imidazole-4-carboxylic acid hydrazide.

1. temperatureat reflux temperature for 3 hours
2. temperaturethe solution was refluxed for 3 days
3. customThe mixture was partially evaporated
4. customthe solid collected
5. washwashed twice with absolute ethanol
6. dry with materialether and dried