Potassium cyanate → HCID 20140046, compound

HRID 1252478Notes

Reaction equation

HRID 1252478 reaction equation
[O-:1][C:2]#[N:3].[K+].[NH2:5][CH:6]1[CH:15]=[CH:14][C:13]2[CH:12]=[N:11][CH:10]=[CH:9][C:8]=2[C:7]1=O>Cl>[NH:3]1[C:7]2[C:8]3[CH:9]=[CH:10][N:11]=[CH:12][C:13]=3[CH2:14][CH2:15][C:6]=2[NH:5][C:2]1=[O:1]

Participants

4

Reactant 2

HCID 11378442Potassium cyanateHCID 14276100HCID 14276100, compound

Product 1

HCID 20140046HCID 20140046, compoundYield 25.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent2×

Procedure

Potassium cyanate (8.63 g, 0.106 mole) was added to a solution of 6-aminoisoquinolin-5-one (5.0 g, 0.0213 mole) in hydrochloric acid (pH=1) while maintaining the acidity constant by subsequent addition of concentrated hydrochloric acid. After stirring for about 11/2 hours, the product precipitated andwas obtained by filtration. Recrystallization from 50% aqueous ethanol gave 1.03 g (25%) of the desired product, m.p. >310° C.

Workup

  1. temperaturewhile maintaining the acidity
  2. customthe product precipitated andwas
  3. customobtained by filtration
  4. customRecrystallization from 50% aqueous ethanol

Sources & evidence

ORD record
ord-bde22ab086ee4371b47cc9b0fac561ce
Source dataset
uspto-grants-1988_05
Patent number
US04743607

Reaction notes

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