HCID 57237301, compound → HCID 86742170, compound

HRID 1252632Notes

Reaction equation

HRID 1252632 reaction equation
CC(C)(OC([NH:7][NH:8][C:9](=[O:27])[CH:10]=[CH:11][C:12]1[NH:13][CH:14]=[C:15]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:16](=[O:18])[CH:17]=1)=O)C>FC(F)(F)C(O)=O>[O:18]=[C:16]1[C:15]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:14][NH:13][C:12]([CH:11]=[CH:10][C:9]([NH:8][NH2:7])=[O:27])=[CH:17]1

Participants

3

Reactant 1

HCID 57237301HCID 57237301, compound

Product 1

HCID 86742170HCID 86742170, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3-[1,4-Dihydro-4-oxo-5-(phenylmethoxy)-2-pyridinyl]-2-propenoic acid, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide (3.86 g) was stirred for one-half hour in 30 ml of trifluoroacetic acid at 0°-5° C. The trifluoroacetic acid salt of the title compound precipitated after adding 50 ml of diethylether. The salt was suspended in 30 ml of water, stirred with 2 g of sodium bicarbonate for 20 minutes, and the title compound was filtered off, washed with water and dried yielding a beige powder. Yield: 2.75 g.

Workup

  1. customThe trifluoroacetic acid salt of the title compound precipitated
  2. additionafter adding 50 ml of diethylether
  3. filtrationthe title compound was filtered off
  4. washwashed with water
  5. customdried
  6. customyielding a beige powder

Sources & evidence

ORD record
ord-7c4a821325f74bbfbfae291af5d8028e
Source dataset
uspto-grants-1988_05
Patent number
US04743685

Reaction notes

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