反应详情

To a suspension of 3.9 g of N-amino-L-proline and 6.06 g of N-methylmorpholine in 200 ml of dimethylacetamide is added 4.98 g of 3-acetylthiopropionyl chloride. The temperature of the reaction mixture rises to 34° spontaneously. The reaction mixture is then heated at 90° for 5 hours and allowed to cool to room temperature overnight. The crystalline solid, N-methylmorpholine hydrochloride, is removed by filtration and the filtrate concentrated under reduced pressure. The residue is dissolved in a minimum amount of 20% hydrochloric acid and the aqueous solution is then extracted with 3×150 ml of ethyl acetate. The ethyl acetate extracts are combined, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to yield the desired N-[[3-(acetylmercapto)-1-oxopropyl]amino]-L-proline.

1. customrises to 34°
2. temperatureThe reaction mixture is then heated at 90° for 5 hours
3. customThe crystalline solid, N-methylmorpholine hydrochloride, is removed by filtration
4. concentrationthe filtrate concentrated under reduced pressure
5. dissolutionThe residue is dissolved in a minimum amount of 20% hydrochloric acid
6. extractionthe aqueous solution is then extracted with 3×150 ml of ethyl acetate
7. dry with materialdried over anhydrous magnesium sulfate
8. concentrationconcentrated under reduced pressure