2-Methylpyrrolidine → HCID 20138007, compound

HRID 1253019Notes

Reaction equation

HRID 1253019 reaction equation
Cl[CH2:2][CH2:3][CH:4]1[CH2:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]2[CH:13]=[CH:14][CH:15]=[N:16][C:6]=2[CH2:5]1.[CH3:17][CH:18]1[CH2:22][CH2:21][CH2:20][NH:19]1>C(O)C>[CH3:17][CH:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:2][CH2:3][CH:4]1[CH2:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]2[CH:13]=[CH:14][CH:15]=[N:16][C:6]=2[CH2:5]1

Participants

4

Reactant 2

HCID 130032-MethylpyrrolidineHCID 14155950HCID 14155950, compound

Product 1

HCID 20138007HCID 20138007, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 8-(2-chloroethyl)-6,7,8,9-tetrahydro-6-methyl-5H-pyrido[3,2-c]azepin-5-one in ethanol was added 2-methylpyrrolidine. The solution is heated to reflux for several hours and ethanol is removed by evaporation. The residue is partitioned between dilute aqueous base and chloroform and the chloroform layer concentrated and the title compound isolated by an appropriate technique, e.g., distillation.

Workup

  1. temperatureThe solution is heated
  2. temperatureto reflux for several hours
  3. customethanol is removed by evaporation
  4. customThe residue is partitioned between dilute aqueous base and chloroform
  5. concentrationthe chloroform layer concentrated

Sources & evidence

ORD record
ord-11ce0dc024864ccc9af5056a0bd5e35a
Source dataset
uspto-grants-1988_05
Patent number
US04746657

Reaction notes

Loading…