Triethylamine → HCID 70415935, compound

HRID 1253183Notes

Reaction equation

HRID 1253183 reaction equation
[Cl:1][C:2]1[C:7]2[O:8][CH2:9][C:10](=[O:12])[NH:11][C:6]=2[N:5]=[C:4]([CH3:13])[N:3]=1.[N:14]1([CH2:20][CH2:21]N)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.C([N:25](CC)CC)C>>[ClH:1].[ClH:1].[CH3:13][C:4]1[N:3]=[C:2]([CH2:21][CH2:20][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:7]2[O:8][CH:9]([NH2:25])[C:10](=[O:12])[NH:11][C:6]=2[N:5]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 4082852-MorpholinoethylamineHCID 608089HCID 608089, compound

Product 1

HCID 70415935HCID 70415935, compoundYield 50.1%

Procedure

According to Example 20, a mixture containing 1 g of 4-chloro-2-methyl-6,7-dihydro-8H-pyrimido[5,4-b][1,4]oxazin-7-one, 1.01 g of triethylamine and 0.65 g of 2-(4-morpholinyl)-ethylamine is refluxed for 40 hours to give 0.46 g (25%) of the product, m.p.: 233°-237° C. (with decomposition).

Workup

  1. temperatureis refluxed for 40 hours

Sources & evidence

ORD record
ord-00fc285dbbf34e12b10fa5c522ff1477
Source dataset
uspto-grants-1988_05
Patent number
US04748175

Reaction notes

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