Acetic Acid → 2-methyl-1H-benzimidazole-5-carboxylic acid

HRID 1253207Notes

Reaction equation

HRID 1253207 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH2:11])[C:5]([OH:7])=[O:6].[C:12](O)(=O)[CH3:13]>Cl>[CH3:12][C:13]1[NH:11][C:10]2[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 692633,4-Diaminobenzoic acid

Product 1

HCID 11326092-methyl-1H-benzimidazole-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

100 g (0.657 mol) of 3,4-diaminobenzoic acid are boiled under reflux with 47.3 g (0.788 mol) of glacial acetic acid and 600 ml of 4N HCl in analogy to Example 14a.

Sources & evidence

ORD record
ord-27c267e0900041729f6643f68feb8e22
Source dataset
uspto-grants-1988_05
Patent number
US04748163

Reaction notes

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