反应详情

6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde (100 mg, 0.365 mmol), hydroxylamine hydrochloride (27.9 mg, 0.401 mmol) and sodium bicarbonate (33.7 mg, 0.401 mmol) were suspended in absolute ethanol (4 ml) and stirred for 1 h (heavy colorless precipitate forms). The mixture was concentrated to dryness, then diluted in 8 mL of water and stirred for 5 minutes. The solid was filtered, washed with water, then placed under vacuum overnight to afford 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbaldehyde oxime as a mixture of oxime isomers.

1. concentrationThe mixture was concentrated to dryness
2. additiondiluted in 8 mL of water
3. stirringstirred for 5 minutes
4. filtrationThe solid was filtered
5. washwashed with water
6. customplaced under vacuum overnight