Dimethylformamide dimethyl acetal → HCID 21807119, compound

HRID 1253476Notes

Reaction equation

HRID 1253476 reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][O:10][C:11](=[O:17])[CH2:12][C:13](=[O:16])[CH2:14][CH3:15]>>[CH3:6][N:4](/[CH:3]=[C:12](/[C:13](=[O:16])[CH2:14][CH3:15])\[C:11]([O:10][CH3:9])=[O:17])[CH3:5]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 121699Methyl 3-oxovalerate

Product 1

HCID 21807119HCID 21807119, compound

Conditions

Temperature
110 °C

Procedure

To N,N-dimethylformamide dimethyl acetal (0.384 ml, 2.88 mmol) was added methyl-3-oxo-pentanoate (250 mg, 1.92 mmol) and the mixture was heated to 110° C. in a sealed vessel. After 30 minutes the reaction mixture was cooled and concentrated to afford methyl (2Z)-2-[(dimethylamino)methylene]-3-oxopentanoate which was used without further purification.

Workup

  1. temperatureAfter 30 minutes the reaction mixture was cooled
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-2b5b938791ef468eb0f35fe04eb5456c
Source dataset
uspto-grants-2013_06
Patent number
US08455477B2

Reaction notes

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