Cyclopropyl methyl ketone → 1207839-99-3

HRID 1253481Notes

Reaction equation

HRID 1253481 reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][C:10]([CH:12]1[CH2:14][CH2:13]1)=[O:11]>>[CH:12]1([C:10](=[O:11])/[CH:9]=[CH:3]/[N:4]([CH3:5])[CH3:6])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 13004Cyclopropyl methyl ketoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 103969151207839-99-3

Conditions

Temperature
150 °C

Procedure

To N,N-dimethylformamide dimethyl acetal (9.51 ml, 71.3 mmol) was added cyclopropyl methyl ketone (3.34 ml, 35.7 mmol) and the mixture was heated to 150° C. in a sealed vessel. After 16 hours, the reaction mixture was cooled and concentrated to afford (2E)-1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one which was used without further purification.

Workup

  1. temperaturethe reaction mixture was cooled
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-5f5eb7e3049247d48ff09a582ffa07a4
Source dataset
uspto-grants-2013_06
Patent number
US08455477B2

Reaction notes

Loading…