Benzoic Acid → HCID 71294308, compound

HRID 1253791Notes

Reaction equation

HRID 1253791 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([NH2:19])[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20](O)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH:1]1([C:7]2[CH:8]=[C:9]([NH:19][C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH:10]=[N:11][C:12]=2[O:13][CH2:14][C:15]([F:16])([F:17])[F:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 243Benzoic AcidHCID 712941485-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine

Product 1

HCID 71294308HCID 71294308, compoundYield 48.1%

Procedure

This compound was prepared following the same procedure as described for Example 3 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine (Example 8b) (100 mg, 0.36 mmol) and benzoic acid (40 mg, 0.33 mmol) as starting materials. The title compound (60 mg, 43.5%) was isolated as off white solid; MS (ESI): 379 [M+H]+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5884380a090542f3ae3aac25e183d3d9
Source dataset
uspto-grants-2013_06
Patent number
US08455501B2

Reaction notes

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