Hydrochloric Acid → HCID 67103768, compound

HRID 1253825Notes

Reaction equation

HRID 1253825 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N:9]2[C:13]3[N:14]=[C:15]([CH3:27])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25][OH:26])[CH2:20][CH2:19]4)[C:12]=3[C:11]([CH3:28])=[CH:10]2)=[C:4]([CH3:29])[CH:3]=1.[ClH:30]>C(O)C.C(OCC)(=O)C>[ClH:30].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([N:9]2[C:13]3[N:14]=[C:15]([CH3:27])[N:16]=[C:17]([N:18]4[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25][OH:26])[CH2:20][CH2:19]4)[C:12]=3[C:11]([CH3:28])=[CH:10]2)=[C:4]([CH3:29])[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10389386HCID 10389386, compound

Product 1

HCID 67103768HCID 67103768, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of 2-{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,5-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperidin-4-yl}-ethanol (6.41 g) in ethanol (51 mL) was added 4 M HCl in ethyl acetate (4.2 mL) under ice-cooling. After removing the solvent, ethyl acetate (26 mL) was added to the residue. The mixture was stirred overnight to afford a white crystal. The crystal was collected by filtration to give the title compound (6.1 g).

Workup

  1. temperaturecooling
  2. customAfter removing the solvent, ethyl acetate (26 mL)
  3. additionwas added to the residue
  4. customto afford a white crystal
  5. filtrationThe crystal was collected by filtration

Sources & evidence

ORD record
ord-775d303840fa4034a88d2d086a191e0b
Source dataset
uspto-grants-2013_06
Patent number
US08455511B2

Reaction notes

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