Hydrochloric Acid → HCID 178510666, compound

HRID 1254018Notes

Reaction equation

HRID 1254018 reaction equation
[C:1]([C:3]1[N:7](COCC[Si](C)(C)C)[N:6]=[C:5]2[CH2:16][N:17](C(OC(C)(C)C)=O)[CH2:18][C:4]=12)#[N:2].Cl>CCO>[N:6]1[NH:7][C:3]([C:1]#[N:2])=[C:4]2[CH2:18][NH:17][CH2:16][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67965001HCID 67965001, compound

Product 1

HCID 178510666HCID 178510666, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

To a stirred solution of the product obtained in Step E (250 mg, 0.686 mmol) in EtOH (4 mL) was added 1N HCl (8 mL). The resulting mixture was heated at 90° C. under nitrogen for 3 h. Solvents were removed and the crude product was subjected to column chromatography on a silica gel Biotage 40S® column, eluting with 5 to 14% MeOH (containing 10% conc. NH4OH) in CH2Cl2 to give the title compound. LC-MS: 135.1 (M+H).

Workup

  1. customSolvents were removed
  2. washeluting with 5 to 14% MeOH (containing 10% conc. NH4OH) in CH2Cl2

Sources & evidence

ORD record
ord-93519b74da98431ba325cb7d2cf5f339
Source dataset
uspto-grants-2013_06
Patent number
US08455533B2

Reaction notes

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