Trifluoroacetic acid → HCID 67958196, compound

HRID 1254019Notes

Reaction equation

HRID 1254019 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][C@@H:12]([N:14]2[CH2:21][C:20]3[C:16](=[N:17][N:18]([CH2:22][C:23]([NH2:25])=[O:24])[CH:19]=3)[CH2:15]2)[CH2:11][O:10][C@@H:9]1[C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[F:33])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C@@H:8]1[C@@H:9]([C:26]2[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=2[F:33])[O:10][CH2:11][C@H:12]([N:14]2[CH2:21][C:20]3[C:16](=[N:17][N:18]([CH2:22][C:23]([NH2:25])=[O:24])[CH:19]=3)[CH2:15]2)[CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131730612HCID 131730612, compound

Product 1

HCID 67958196HCID 67958196, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from Step A (433 mg, 0.907 mmol) in CH2Cl2 (60 mL) was treated with TFA (60 mL) at RT for 2 h. After removing the TFA/CH2Cl2, the residue was purified on a silica gel column and eluting with 2.5-5% MeOH (containing 10% NH4OH)/CH2Cl2 to give the title compound. LC-MS=378.04 [M+1].

Workup

  1. customAfter removing the TFA/CH2Cl2
  2. customthe residue was purified on a silica gel column
  3. washeluting with 2.5-5% MeOH (containing 10% NH4OH)/CH2Cl2

Sources & evidence

ORD record
ord-3bec60615e5a441e8790368c66a83c83
Source dataset
uspto-grants-2013_06
Patent number
US08455533B2

Reaction notes

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