HCID 44554074, compound → HCID 178484328, compound

HRID 1254056Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[N:13]([CH3:14])[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:11][C:10]=2[C:21]2[CH:29]=[CH:28][C:24]([C:25]([NH2:27])=[O:26])=[CH:23][CH:22]=2)=[CH:4][CH:3]=1>COC(OC)N(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[N:13]([CH3:14])[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:11][C:10]=2[C:21]2[CH:22]=[CH:23][C:24]([C:25](/[N:27]=[CH:12]/[N:13]([CH3:14])[CH3:9])=[O:26])=[CH:28][CH:29]=2)=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 120 °C

Procedure

A mixture of 4-{5-[(4-chlorophenyl)thio]-1-methyl-2-phenyl-1H-imidazol-4-yl}benzamide (Example 71, 35 mg, 0.083 mmol) in 3 mL of dimethylformamide-dimethylacetal was heated at 120° C. for 30 min. The volatiles were removed to afford 4-{5-[(4-chlorophenyl)thio]-1-methyl-2-phenyl-1H-imidazol-4-yl}-N-[(1E)-(dimethylamino)methylene]benzamide, which was used in the next step without further purification.

Workup

customThe volatiles were removed

Sources & evidence

ORD record: ord-b7e5ad27536f40fb82a893cdddced6d0
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08455528B2

Reaction notes

Loading…