反应详情

To the solution of 70%-allylhydrazine 7.73 g (75 mmol) and triethylamine 8.38 ml (60 mmol), ethyl 2-bromoacetate in dichloromethane 25 ml was added and stirred at room temperature for 24 hours and reflux for additional 1 hour. The reaction mixture was diluted with ethyl acetate 150 ml and washed with brine 100 ml. The organic phase was dried with magnesium sulfate and filtered and the mother solution was concentrated in vacuo to obtain the title compound 6.90 g (87%).

1. temperaturereflux for additional 1 hour
2. washwashed with brine 100 ml
3. dry with materialThe organic phase was dried with magnesium sulfate
4. filtrationfiltered
5. concentrationthe mother solution was concentrated in vacuo