反应详情

To a solution of ethyl 2-(3-fluorophenyl)-2-(3-fluorophenylamino)-acetate (2.00 g, 6.81 mmol) in THF/H2O (1:1 mixture, 10 mL), is added LiOH (816 mg, 34.0 mmol) and the mixture is reacted for 2 hours at RT (LC-MS monitoring: complete conversion). 1N HCl (15 mL) is added and the desired compound is extracted with EtOAc. The resulting crude is purified by flash chromatography (Hexane/EtOAc=1/1) in order to obtain 1.79 g of I11 as a pale yellow solid (99% yield).

1. customthe mixture is reacted for 2 hours at RT (LC-MS monitoring: complete conversion)
2. extractionthe desired compound is extracted with EtOAc
3. customThe resulting crude is purified by flash chromatography (Hexane/EtOAc=1/1) in order