反应详情

温度

120 °C

N-methylaniline (299 ul, 2.76 mmol) is added to a solution of (S)-methyl 2-(methylsulfonyloxy)-2-phenylacetate (I5) (450 mg, 1.84 mmol) in acetonitrile (10 mL). The reaction is heated at 120° C. for 15 minutes (microwave irradiation). 2N HCl (5 mL) is added and the mixture is extracted with EtOAc. The organic phase is dried over sodium sulphate and the solvent is evaporated to dryness. The crude is purified by flash chromatography on silica gel (Petroleum ether/Et2O=9/1) to obtain intermediate I121 as an orange amorphous solid (125 mg, 27% yield).

1. custom(microwave irradiation)
2. extractionthe mixture is extracted with EtOAc
3. dry with materialThe organic phase is dried over sodium sulphate
4. customthe solvent is evaporated to dryness
5. customThe crude is purified by flash chromatography on silica gel (Petroleum ether/Et2O=9/1)