Aluminium lithium hydride → HCID 24765214, compound

HRID 1255118Notes

Reaction equation

HRID 1255118 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[C:10]([C:12](OC)=[O:13])[N:11]=1)=[O:5].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=2)=[C:10]([CH2:12][OH:13])[N:11]=1)=[O:5]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 24765116HCID 24765116, compound

Product 1

HCID 24765214HCID 24765214, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by reducing Methyl 2-(2,6-difluorobenzamido)-5-(3-fluorophenyl)thiazole-4-carboxylate with lithium aluminum hydride (2 equiv) in THF. Yield: 92%. H-NMR(CDCl3) 7.50-6.90 (7H, m), 4.60 (2H, s). MS (ESI) [MH+] 365.

Sources & evidence

ORD record
ord-96f740ad907c493d84413842738e68ff
Source dataset
uspto-grants-2013_06
Patent number
US08455658B2

Reaction notes

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