反应详情

温度

65 °C

Into a solution of Compound 67 (62 mg, 0.15 mmol) in 5 mL of dry methanol was added tosylmethyl isocyanide (35 mg, 0.18 mmol), followed by dry potassium carbonate (25 mg, 0.18 mmol). The reaction mixture was heated to 65° C. for 2 hours. The reaction mixture was dissolved in ethyl acetate, washed each with water and brine, dried (Na2SO4) and concentrated. The residue was purified by column chromatography on silica gel (eluted with 10-50% ethyl acetate in hexanes) to give Compound 76 (49 mg, 72%) as a white solid.

1. washwashed each with water and brine
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated
4. customThe residue was purified by column chromatography on silica gel (eluted with 10-50% ethyl acetate in hexanes)