反应详情

温度

70 °C

Ethyl chloroformate (5.00 ml, 52.1 mmol) was added to a solution of 2-amino-4-bromobenzoic acid (3.75 g, 17.36 mmol) in THF (70 ml) at room temperature. The mixture was heated to 70° C. and let stir for 24 hrs. The reaction was concentrated to give an oily solid. The resulting solid was diluted with toluene (50 mL), concentrated and then triturated with 5% ether/hexanes (100 mL) to give upon filtration and subsequent washing of the solid with hexane the title compound (4.6 gm, 92%) as a solid. LCMS (ES+) m/z 287.88 (M+H)+.

1. concentrationThe reaction was concentrated
2. customto give an oily solid
3. concentrationconcentrated
4. customtriturated with 5% ether/hexanes (100 mL)
5. customto give upon filtration
6. washsubsequent washing of the solid with hexane the title compound (4.6 gm, 92%) as a solid