Hydrochloric Acid → 1-(3-Bromophenyl)ethanamine

A mixture of 3′-bromoacetophenone (2.66 mL, 20 mmol), ammonium formate (6.31 g, 100 mmol) and dichloro(pentamethylcyclopentadienyl)rhodium(III) dimer (124 mg, 0.2 mmol) in anhydrous methanol (20 mL) under an atmosphere of nitrogen was heated at reflux for 5 hours then allowed to cool to room temperature overnight. The mixture was diluted with water (20 mL), acidified to pH 2 with dilute aqueous hydrochloric acid (2M) and washed with dichloromethane (2×60 mL). The aqueous solution was basified to pH 12 with solid potassium hydroxide, extracted with dichloromethane (3×50 mL) and the extracts washed with brine (50 mL), dried (Na2SO4) and concentrated under reduced pressure to give 1-(3-bromophenyl)ethanamine (3.4 mg, 85%) as a yellow liquid.

1. temperaturewas heated
2. temperatureat reflux for 5 hours
3. washwashed with dichloromethane (2×60 mL)
4. extractionextracted with dichloromethane (3×50 mL)
5. washthe extracts washed with brine (50 mL)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated under reduced pressure

ORD record

ord-0f2c8b8abbd44aa49c644c9fcf7dadab

Source dataset

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08461161B2