Potassium Carbonate → HCID 68777862, compound

HRID 1255866Notes

Reaction equation

HRID 1255866 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[C:9]([C:11]3[CH:12]=[N:13][C:14](F)=[CH:15][CH:16]=3)[CH:8]=[N:7][C:6]=12.[NH2:18][CH2:19][C:20]([CH3:23])([OH:22])[CH3:21].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH:18][CH2:19][C:20]([CH3:23])([OH:22])[CH3:21])=[N:13][CH:12]=3)[CH:8]=[N:7][C:6]=12

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 951022-Propanol, 1-amino-2-methyl-HCID 59603832HCID 59603832, compound

Product 1

HCID 68777862HCID 68777862, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 3-bromo-6-(6-fluoropyridin-3-yl)pyrazolo[1,5-a]pyrimidine (0.1 g, 0.34 mmol), 1-amino-2-methylpropan-2-ol (0.06 g, 0.68 mmol) and potassium carbonate (0.9 g, 0.68 mmol) in DMF (3 mL) was heated to 80° C. for 72 hours. The reaction was directly purified by reverse phase LC to give 1-{[5-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)pyridin-2-yl]amino}-2-methylpropan-2-ol. LC-MS EIMS: m/z 364.0 [M+H]+.

Workup

  1. customThe reaction was directly purified by reverse phase LC

Sources & evidence

ORD record
ord-66cec96ec0f8496d97cd4fa3bfbf6c48
Source dataset
uspto-grants-2013_06
Patent number
US08461162B2

Reaction notes

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