Pyridine → 1-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one Oxime

HRID 12559Notes

Reaction equation

HRID 12559 reaction equation
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19](=O)[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:23][OH:24].Cl.N1C=CC=CC=1>CCO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19](=[N:23][OH:24])[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 250331671-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one2×

Product 1

HCID 1363323391-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one Oxime

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following General Procedure P, 1-(5,6-diphenyl-pyridin-2-yl)-propan-1-one (Compound 76, 90 mg, 0.31 mmol), NH2OH—HCl (87 mg, 1.25 mmol) and pyridine (272 mg, 0.27 mmol) in EtOH (2 ml) were reacted to give title compound as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-de35d10a8fda445dbd46ff8369b0ab92
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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